Source:http://linkedlifedata.com/resource/pubmed/id/20580555
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
15
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pubmed:dateCreated |
2010-7-16
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pubmed:abstractText |
A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties in positions 3-, 4-, 6- and 7- of the heterocyclic ring were investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). These coumarins were very weak or ineffective as inhibitors of the house-keeping, offtarget isoforms CA I and II, but showed effective, submicromolar inhibition of the transmembrane, tumor-associated isoforms CA IX and XII. The nature and position of the groups substituting the coumarin ring greatly influenced CA inhibitory properties. 6-Hydroxycoumarin showed K(I)s >100 microM against CA I and II, of 0.198 microM against CA IX and of 0.683 microM against CA XII, being thus a selective, efficient inhibitor for the tumor-associated over cytosolic isoforms. These compounds are also excellent leads for designing isoform-selective enzyme inhibitors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CA9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrase I,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrase II,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrases,
http://linkedlifedata.com/resource/pubmed/chemical/Coumarins,
http://linkedlifedata.com/resource/pubmed/chemical/carbonic anhydrase XII
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4511-4
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pubmed:meshHeading |
pubmed-meshheading:20580555-Antigens, Neoplasm,
pubmed-meshheading:20580555-Binding Sites,
pubmed-meshheading:20580555-Carbonic Anhydrase I,
pubmed-meshheading:20580555-Carbonic Anhydrase II,
pubmed-meshheading:20580555-Carbonic Anhydrase Inhibitors,
pubmed-meshheading:20580555-Carbonic Anhydrases,
pubmed-meshheading:20580555-Computer Simulation,
pubmed-meshheading:20580555-Coumarins,
pubmed-meshheading:20580555-Humans,
pubmed-meshheading:20580555-Neoplasms
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pubmed:year |
2010
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pubmed:articleTitle |
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.
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pubmed:affiliation |
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino (Firenze), Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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