Linked Life Data

20579985

Source:http://linkedlifedata.com/resource/pubmed/id/20579985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2010-7-8
pubmed:abstractText
Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1873-3468
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
584
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3233-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.
pubmed:affiliation
Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, Kumamoto, Japan. noel@da2.so-net.ne.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't