Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-3
pubmed:abstractText
Hemorrhage and hemorrhagic shock instigate intestinal damage and inflammation. Multiple components of the innate immune response, including complement and neutrophil infiltration, are implicated in this pathology. To investigate the interaction of complement activation and other components of the innate immune response during hemorrhage, we treated mice after hemorrhage with CR2-fH, a targeted inhibitor of the alternative complement pathway and assessed intestinal damage and inflammation 2 h after hemorrhage. In wild-type mice, CR2-fH attenuated hemorrhage-induced, midjejunal damage and inflammation as determined by decreased mucosal damage, macrophage infiltration, leukotriene B4, IL-12p40, and TNF-[alpha] production. The critical nature of intestinal macrophage infiltration and activation in the response to hemorrhage was further determined using mice pretreated with clodronate-containing liposomes. The absence of either macrophages or IL-12p70 attenuated intestinal damage. These data suggest that complement activation and macrophage infiltration with IL-12p70 production are critical to hemorrhage-induced midjejunal damage and inflammation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1540-0514
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
134-40
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:20577145-Animals, pubmed-meshheading:20577145-Bone Density Conservation Agents, pubmed-meshheading:20577145-Clodronic Acid, pubmed-meshheading:20577145-Complement Activation, pubmed-meshheading:20577145-Complement Inactivating Agents, pubmed-meshheading:20577145-Complement System Proteins, pubmed-meshheading:20577145-Immunity, Innate, pubmed-meshheading:20577145-Interleukin-12, pubmed-meshheading:20577145-Intestinal Diseases, pubmed-meshheading:20577145-Intestines, pubmed-meshheading:20577145-Leukotriene B4, pubmed-meshheading:20577145-Macrophage Activation, pubmed-meshheading:20577145-Macrophages, pubmed-meshheading:20577145-Mice, pubmed-meshheading:20577145-Mice, Knockout, pubmed-meshheading:20577145-Neutrophil Infiltration, pubmed-meshheading:20577145-Neutrophils, pubmed-meshheading:20577145-Shock, Hemorrhagic, pubmed-meshheading:20577145-Time Factors, pubmed-meshheading:20577145-Tumor Necrosis Factor-alpha
pubmed:year
2011
pubmed:articleTitle
Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner.
pubmed:affiliation
Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural