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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
35
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pubmed:dateCreated |
2010-8-23
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pubmed:abstractText |
Art v 1, the major pollen allergen of the composite plant mugwort (Artemisia vulgaris) has been identified recently as a thionin-like protein with a bulky arabinogalactan-protein moiety. A close relative of mugwort, ragweed (Ambrosia artemisiifolia) is an important allergen source in North America, and, since 1990, ragweed has become a growing health concern in Europe as well. Weed pollen-sensitized patients demonstrated IgE reactivity to a ragweed pollen protein of apparently 29-31 kDa. This reaction could be inhibited by the mugwort allergen Art v 1. The purified ragweed pollen protein consisted of a 57-amino acid-long defensin-like domain with high homology to Art v 1 and a C-terminal proline-rich domain. This part contained hydroxyproline-linked arabinogalactan chains with one galactose and 5 to 20 and more alpha-arabinofuranosyl residues with some beta-arabinoses in terminal positions as revealed by high field NMR. The ragweed protein contained only small amounts of the single hydroxyproline-linked beta-arabinosyl residues, which form an important IgE binding determinant in Art v 1. cDNA clones for this protein were obtained from ragweed flowers. Immunological characterization revealed that the recombinant ragweed protein reacted with >30% of the weed pollen allergic patients. Therefore, this protein from ragweed pollen constitutes a novel important ragweed allergen and has been designated Amb a 4.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-10725439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-10846754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-11154705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-11393510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-12475905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-12704373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-1381156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-15283880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-15591314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-16254437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-16650052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-16890775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-17689599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-17823540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-17854785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-18588553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-18925891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-19082981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-19216534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-2674263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-2849754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-5781008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-7304940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-7573960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-7830586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-7978269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-8939153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-8995418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576600-9500752
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Plant,
http://linkedlifedata.com/resource/pubmed/chemical/Art v 1 protein, mugwort,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Galactans,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/arabinogalactan
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1083-351X
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pubmed:author |
pubmed-author:AltmannFriedrichF,
pubmed-author:DuusJens ØJØ,
pubmed-author:FerreiraFatimaF,
pubmed-author:GadermaierGabrieleG,
pubmed-author:HimlyMartinM,
pubmed-author:LéonardRenaudR,
pubmed-author:PabstMartinM,
pubmed-author:PetersenBent OBO,
pubmed-author:RadauerChristianC,
pubmed-author:Razzazi-FazeliEbrahimE,
pubmed-author:StadlmannJohannesJ,
pubmed-author:WopfnerNicoleN
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27192-200
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pubmed:dateRevised |
2011-8-30
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pubmed:meshHeading |
pubmed-meshheading:20576600-Allergens,
pubmed-meshheading:20576600-Ambrosia,
pubmed-meshheading:20576600-Antigens, Plant,
pubmed-meshheading:20576600-Artemisia,
pubmed-meshheading:20576600-DNA, Complementary,
pubmed-meshheading:20576600-Europe,
pubmed-meshheading:20576600-Galactans,
pubmed-meshheading:20576600-Humans,
pubmed-meshheading:20576600-Immunoglobulin E,
pubmed-meshheading:20576600-North America,
pubmed-meshheading:20576600-Plant Proteins,
pubmed-meshheading:20576600-Pollen,
pubmed-meshheading:20576600-Protein Structure, Tertiary,
pubmed-meshheading:20576600-Rhinitis, Allergic, Seasonal,
pubmed-meshheading:20576600-Sequence Homology, Amino Acid
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pubmed:year |
2010
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pubmed:articleTitle |
A new allergen from ragweed (Ambrosia artemisiifolia) with homology to art v 1 from mugwort.
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pubmed:affiliation |
Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, 1190 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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