Linked Life Data

20576574

Source:http://linkedlifedata.com/resource/pubmed/id/20576574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-6-25
pubmed:abstractText
To search multi drug resistance modulators, acridones carrying hydroxyl amine substituent at N-10 and COOH/Cl at C-4 were investigated for their interactions with the three components of efflux pump viz. P-gp, ATP, and Mg(2+). Experimental and theoretical results indicated that the compounds with COOH group at C-4 interact with P-gp and Mg(2+) while other set of compounds with Cl at C-4 interact with ATP and Mg(2+). Spot assay and R6G influx/efflux assay of compound 3 using Candida albicans showed decrease in the fungal growth and efflux of R6G, respectively, in presence of compound 3 suggesting the suitability of this compound for MDR modulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1464-3391
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4212-23
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation.
pubmed:affiliation
Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India. palwinder_singh_2000@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't