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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0039198,
umls-concept:C0079411,
umls-concept:C0229792,
umls-concept:C0597140,
umls-concept:C0965743,
umls-concept:C1171362,
umls-concept:C1332714,
umls-concept:C1416467,
umls-concept:C1515670,
umls-concept:C1705357
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pubmed:issue |
13
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pubmed:dateCreated |
2010-10-1
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pubmed:abstractText |
Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance. Deficiencies of B7-H1 and B7-DC abrogated the oral tolerance, accompanied by enhanced antigen-specific CD4(+) T-cell response and IgG(1) production. Mesenteric lymph node (MLN) dendritic cells (DCs) displayed higher levels of B7-H1 and B7-DC than systemic DCs, whereas they showed similar levels of CD80, CD86, and B7-H2. MLN DCs enhanced the antigen-specific generation of CD4(+)Foxp3(+) inducible regulatory T cells (iT(regs)) from CD4(+)Foxp3(-) T cells rather than CD4(+) effector T cells (T(eff)) relative to systemic DCs, owing to the dominant expression of B7-H1 and B7-DC. Furthermore, the antigen-specific conversion of CD4(+)Foxp3(-) T cells into CD4(+)Foxp3(+) iT(regs) occurred in MLNs greater than in peripheral organs during oral tolerance under steady-state conditions, and such conversion required B7-H1 and B7-DC more than other B7 family members, whereas it was severely impaired under inflammatory conditions. In conclusion, our findings suggest that B7-H1 and B7-DC expressed on MLN DCs are essential for establishing oral tolerance through the de novo generation of antigen-specific CD4(+)Foxp3(+) iT(regs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:AzumaMiyukiM,
pubmed-author:ChenLiepingL,
pubmed-author:DongChenC,
pubmed-author:EizumiKaworiK,
pubmed-author:FukayaTomohiroT,
pubmed-author:MalissenBernardB,
pubmed-author:SatoKaoriK,
pubmed-author:SatoKatsuakiK,
pubmed-author:SatoYumikoY,
pubmed-author:ShinTahiroT,
pubmed-author:TakagiHideakiH,
pubmed-author:TayaHonamiH,
pubmed-author:YagitaHideoH
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
116
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2266-76
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20574047-Administration, Oral,
pubmed-meshheading:20574047-Animals,
pubmed-meshheading:20574047-Antigen Presentation,
pubmed-meshheading:20574047-Antigens,
pubmed-meshheading:20574047-Antigens, CD274,
pubmed-meshheading:20574047-Antigens, CD80,
pubmed-meshheading:20574047-Dendritic Cells,
pubmed-meshheading:20574047-Forkhead Transcription Factors,
pubmed-meshheading:20574047-Immune Tolerance,
pubmed-meshheading:20574047-Immunoglobulin G,
pubmed-meshheading:20574047-Lymph Nodes,
pubmed-meshheading:20574047-Membrane Glycoproteins,
pubmed-meshheading:20574047-Mesentery,
pubmed-meshheading:20574047-Mice,
pubmed-meshheading:20574047-Mice, Inbred BALB C,
pubmed-meshheading:20574047-Mice, Inbred C57BL,
pubmed-meshheading:20574047-Mice, Knockout,
pubmed-meshheading:20574047-Mice, Transgenic,
pubmed-meshheading:20574047-Ovalbumin,
pubmed-meshheading:20574047-Peptides,
pubmed-meshheading:20574047-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:20574047-Receptors, Antigen, T-Cell,
pubmed-meshheading:20574047-Recombinant Proteins,
pubmed-meshheading:20574047-T-Lymphocytes, Regulatory
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pubmed:year |
2010
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pubmed:articleTitle |
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
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pubmed:affiliation |
Laboratory for Dendritic Cell Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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