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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT(1)R) are efficacious for bronchoconstriction in humans with bronchial asthma; however, the clinical response to these drugs is heterogeneous. In particular, how CysLT(1)R expression and function are constitutively regulated in vivo is not known. In this study, we show that a seven-transmembrane receptor, GPR17, negatively regulates the CysLT(1)R-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, the levels of IgE and specific IgG1 in serum, and Th2/Th17 cytokine expression in the lung after intranasal sensitization and challenge with the house dust mite (extract of Dermatophagoides farinae [Df]) in mice. Sensitization of naive wild-type recipients with Df-pulsed bone marrow-derived dendritic cells of each genotype or sensitization of each genotype with Df-pulsed wild-type bone marrow-derived dendritic cells and Df challenge revealed markedly increased pulmonary inflammatory and serum IgE responses for GPR17-deficient mice as compared with wild-type mice and reduced responses in the genotypes lacking CysLT(1)R. These findings reveal a constitutive negative regulation of CysLT(1)R functions by GPR17 in both the Ag presentation and downstream phases of allergic pulmonary inflammation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/GPR17 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1846-54
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:20574000-Allergens,
pubmed-meshheading:20574000-Animals,
pubmed-meshheading:20574000-Antigen Presentation,
pubmed-meshheading:20574000-Cell Movement,
pubmed-meshheading:20574000-Dermatophagoides farinae,
pubmed-meshheading:20574000-Desensitization, Immunologic,
pubmed-meshheading:20574000-Dose-Response Relationship, Immunologic,
pubmed-meshheading:20574000-Female,
pubmed-meshheading:20574000-Immunoglobulin E,
pubmed-meshheading:20574000-Immunoglobulin G,
pubmed-meshheading:20574000-Inflammation,
pubmed-meshheading:20574000-Interleukin-17,
pubmed-meshheading:20574000-Lung,
pubmed-meshheading:20574000-Lymph Nodes,
pubmed-meshheading:20574000-Male,
pubmed-meshheading:20574000-Mice,
pubmed-meshheading:20574000-Mice, Inbred C57BL,
pubmed-meshheading:20574000-Mice, Knockout,
pubmed-meshheading:20574000-Nerve Tissue Proteins,
pubmed-meshheading:20574000-Receptors, G-Protein-Coupled,
pubmed-meshheading:20574000-Receptors, Leukotriene,
pubmed-meshheading:20574000-Respiratory Hypersensitivity,
pubmed-meshheading:20574000-Th2 Cells
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pubmed:year |
2010
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pubmed:articleTitle |
GPR17 regulates immune pulmonary inflammation induced by house dust mites.
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pubmed:affiliation |
Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA. amaekawa@rics.bwh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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