Linked Life Data

20570674

Source:http://linkedlifedata.com/resource/pubmed/id/20570674

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2010-10-11
pubmed:abstractText
In response to skeletal muscle injury, distinct cellular pathways are activated to repair the damaged tissue. Activation and restriction of these pathways must be temporally coordinated in a precise sequence as regeneration progresses if muscle integrity and homeostasis are to be restored. However, if tissue injury persists, as in severe muscular dystrophies, the repair process becomes uncontrolled leading to the substitution of myofibers by a non-functional mass of fibrotic tissue. In this review, we provide an overview of how muscle responds to damage and aging, with special emphasis on the cellular effectors and the regulatory and inflammatory pathways that can shift normal muscle repair to fibrosis development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1090-2422
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3050-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Regulation and dysregulation of fibrosis in skeletal muscle.
pubmed:affiliation
Pompeu Fabra University, Department of Experimental and Life Sciences, Cell Biology Unit, CIBERNED, Dr. Aiguader 88, Barcelona, Spain. antonio.serrano@upf.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't