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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
Alcohol-sensitive type 1 equilibrative nucleotide transporter (ENT1) is known to regulate glutamate signaling in the striatum as well as ethanol intoxication. However, it was unclear whether altered extracellular glutamate levels in ENT1(-/-) mice contribute to ethanol-induced behavioral changes. Here we report that altered glutamate signaling in ENT1(-/-) mice is implicated in the ethanol-induced locomotion and ataxia by NMDA receptor antagonist, CGP37849. ENT1(-/-) mice appear less intoxicated following sequential treatment with CGP37849 and ethanol, compared to ENT1(+/+) littermates on the rotarod. These results indicate that inhibiting NMDA glutamate receptors is critical to regulate the response and susceptibility of alcohol related behaviors. Interestingly, a microdialysis experiment showed that the ventral striatum of ENT1(-/-) mice is less sensitive to the glutamate-reducing effect of the NMDA receptor antagonist compared to the dorsal striatum. Our findings suggest that differential glutamate neurotransmission in the striatum regulates ethanol intoxication.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-11236845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-11283304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-12163677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-12351935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-12451148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-15258586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-15555683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-15608650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-16251991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-16487603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-16499494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-16715055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-17018287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-17376149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-17706608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-18262663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-18440150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-18632551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-18778401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-19005054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-19097273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-19198605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-19222701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-19571793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-20085785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-2166916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-2298733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-7485836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-8770787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-9016298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-9138726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-9354323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20570605-9509257
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1872-7972
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
479
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-81
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pubmed:dateRevised |
2011-8-4
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pubmed:meshHeading |
pubmed-meshheading:20570605-2-Amino-5-phosphonovalerate,
pubmed-meshheading:20570605-Animals,
pubmed-meshheading:20570605-Ataxia,
pubmed-meshheading:20570605-Corpus Striatum,
pubmed-meshheading:20570605-Equilibrative Nucleoside Transporter 1,
pubmed-meshheading:20570605-Ethanol,
pubmed-meshheading:20570605-Glutamic Acid,
pubmed-meshheading:20570605-Male,
pubmed-meshheading:20570605-Mice,
pubmed-meshheading:20570605-Mice, Knockout,
pubmed-meshheading:20570605-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
2010
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pubmed:articleTitle |
Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.
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pubmed:affiliation |
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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