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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-11-1
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pubmed:abstractText |
Alzheimer's disease (AD) is a chronic neurodegenerative disorder whose initiating events are not known. Increasing evidence suggests that oxidative stress and inflammation play a role in its pathogenesis. 12/15 Lipoxygenase (12/15LO) by oxidizing polyunsaturated fatty acids forms hydroperoxyacids, which are potent pro-oxidants and inflammatory mediators. Previously, we reported that this metabolic pathway is increased in AD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
922-9
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pubmed:meshHeading |
pubmed-meshheading:20570249-Alzheimer Disease,
pubmed-meshheading:20570249-Amyloid Precursor Protein Secretases,
pubmed-meshheading:20570249-Amyloid beta-Peptides,
pubmed-meshheading:20570249-Amyloid beta-Protein Precursor,
pubmed-meshheading:20570249-Animals,
pubmed-meshheading:20570249-Arachidonate 12-Lipoxygenase,
pubmed-meshheading:20570249-Arachidonate 15-Lipoxygenase,
pubmed-meshheading:20570249-Brain,
pubmed-meshheading:20570249-Cell Line, Transformed,
pubmed-meshheading:20570249-Cognition Disorders,
pubmed-meshheading:20570249-Disease Models, Animal,
pubmed-meshheading:20570249-Female,
pubmed-meshheading:20570249-Mice,
pubmed-meshheading:20570249-Mice, Knockout,
pubmed-meshheading:20570249-Mice, Transgenic,
pubmed-meshheading:20570249-Plaque, Amyloid,
pubmed-meshheading:20570249-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
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pubmed:affiliation |
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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