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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2011-3-25
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pubmed:abstractText |
Three pyrimidine nucleosides with differently substituted phenyltriazoles attached to the 5-position were prepared by Cu(I)-assisted azide-alkyne cycloadditions (CuAAC) and incorporated into oligonucleotides. Efficient ?-?-stacking between two or more phenyltriazoles in the major groove was found to increase the thermal stability of a DNA:RNA duplex significantly. The best stacking, and most stable duplex, was obtained by a sulfonamide substituted derivative.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4702-10
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pubmed:meshHeading |
pubmed-meshheading:20570158-Alkynes,
pubmed-meshheading:20570158-Azides,
pubmed-meshheading:20570158-Catalysis,
pubmed-meshheading:20570158-Circular Dichroism,
pubmed-meshheading:20570158-Copper,
pubmed-meshheading:20570158-DNA,
pubmed-meshheading:20570158-Deoxyuridine,
pubmed-meshheading:20570158-Models, Molecular,
pubmed-meshheading:20570158-Nucleic Acid Hybridization,
pubmed-meshheading:20570158-RNA
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pubmed:year |
2010
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pubmed:articleTitle |
Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridines.
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pubmed:affiliation |
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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