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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-23
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pubmed:abstractText |
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfr3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Olig2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1875-9777
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pubmed:author |
pubmed-author:FancyStephen P JSP,
pubmed-author:FranklinRobin J MRJ,
pubmed-author:GoncharevichAlexanderA,
pubmed-author:JamenFrançoiseF,
pubmed-author:KessarisNicolettaN,
pubmed-author:PohlHartmutH,
pubmed-author:RichardsonWilliam DWD,
pubmed-author:RiversLeanne ELE,
pubmed-author:RizziMatteoM,
pubmed-author:RowitchDavid HDH,
pubmed-author:SuterUeliU,
pubmed-author:TripathiRichaR,
pubmed-author:YoungKayleneK,
pubmed-author:ZawadzkaMalgorzataM,
pubmed-author:ZhaoChaoC
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
578-90
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pubmed:meshHeading |
pubmed-meshheading:20569695-Adult Stem Cells,
pubmed-meshheading:20569695-Animals,
pubmed-meshheading:20569695-Astrocytes,
pubmed-meshheading:20569695-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:20569695-Cells, Cultured,
pubmed-meshheading:20569695-Central Nervous System,
pubmed-meshheading:20569695-Demyelinating Diseases,
pubmed-meshheading:20569695-Disease Models, Animal,
pubmed-meshheading:20569695-Female,
pubmed-meshheading:20569695-Integrases,
pubmed-meshheading:20569695-Lysophosphatidylcholines,
pubmed-meshheading:20569695-Mice,
pubmed-meshheading:20569695-Mice, Transgenic,
pubmed-meshheading:20569695-Microscopy,
pubmed-meshheading:20569695-Multiple Sclerosis,
pubmed-meshheading:20569695-Nerve Regeneration,
pubmed-meshheading:20569695-Nerve Tissue Proteins,
pubmed-meshheading:20569695-Oligodendroglia,
pubmed-meshheading:20569695-Receptor, Fibroblast Growth Factor, Type 3,
pubmed-meshheading:20569695-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:20569695-Schwann Cells
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pubmed:year |
2010
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pubmed:articleTitle |
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
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pubmed:affiliation |
MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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