Source:http://linkedlifedata.com/resource/pubmed/id/20566490
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-8-10
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| pubmed:abstractText |
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by many cells and tissues including pancreatic beta-cells, liver, skeletal muscle, and adipocytes. This study investigates the potential role of MIF in carbohydrate homeostasis in a physiological setting outside of severe inflammation, utilizing Mif knockout (MIF-/-) mice. Compared with wild-type (WT) mice, MIF-/- mice had a lower body weight, from birth until 4 months of age, but subsequently gained weight faster, resulting in a higher body weight at 12 months of age. The lower weight in young mice was related to a higher energy expenditure, and the higher weight in older mice was related to an increased food intake and a higher fat mass. Fasting blood insulin level was higher in MIF-/- mice compared with WT mice at any age. After i.p. glucose injection, the elevation of blood insulin level was higher in MIF-/- mice compared with WT mice, at 2 months of age, but was lower in 12-month-old MIF-/- mice. As a result, the glucose clearance during intraperitoneal glucose tolerance tests was higher in MIF-/- mice compared with WT mice until 4 months of age, and was lower in 12-month-old MIF-/- mice. Insulin resistance was estimated (euglycemic-hyperinsulinemic clamp tests), and the phosphorylation activity of AKT was similar in MIF-/- mice and WT mice. In conclusion, this mouse model provides evidence for the role of MIF in the control of glucose homeostasis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Migration-Inhibitory...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1479-6805
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| pubmed:author |
pubmed-author:BühlerLéoL,
pubmed-author:BerneyThierryT,
pubmed-author:BoscoDomenicoD,
pubmed-author:CalandraThierryT,
pubmed-author:Gonelle-GispertCarmenC,
pubmed-author:JamesRichard WRW,
pubmed-author:MontetXavierX,
pubmed-author:MorelPhilippeP,
pubmed-author:RogerThierryT,
pubmed-author:Rohner-JeanrenaudFrançoiseF,
pubmed-author:Serre-BeinierVéroniqueV,
pubmed-author:TosoChristianC,
pubmed-author:Veyrat-DurebexChristelleC
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
206
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
297-306
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:20566490-Age Factors,
pubmed-meshheading:20566490-Analysis of Variance,
pubmed-meshheading:20566490-Animals,
pubmed-meshheading:20566490-Blood Glucose,
pubmed-meshheading:20566490-Blotting, Western,
pubmed-meshheading:20566490-Body Composition,
pubmed-meshheading:20566490-Body Weight,
pubmed-meshheading:20566490-Energy Metabolism,
pubmed-meshheading:20566490-Glucose Clamp Technique,
pubmed-meshheading:20566490-Glucose Tolerance Test,
pubmed-meshheading:20566490-Homeostasis,
pubmed-meshheading:20566490-Insulin,
pubmed-meshheading:20566490-Insulin Resistance,
pubmed-meshheading:20566490-Leptin,
pubmed-meshheading:20566490-Lipids,
pubmed-meshheading:20566490-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:20566490-Mice,
pubmed-meshheading:20566490-Mice, Inbred C57BL,
pubmed-meshheading:20566490-Mice, Knockout,
pubmed-meshheading:20566490-Motor Activity,
pubmed-meshheading:20566490-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20566490-Statistics, Nonparametric
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| pubmed:year |
2010
|
| pubmed:articleTitle |
Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice.
|
| pubmed:affiliation |
Surgical Research Unit, Department of Surgery Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland. veronique.serre@unige.ch
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|