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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-5
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pubmed:abstractText |
Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI 69501,
http://linkedlifedata.com/resource/pubmed/grant/AI068636,
http://linkedlifedata.com/resource/pubmed/grant/AI069994,
http://linkedlifedata.com/resource/pubmed/grant/AI40384,
http://linkedlifedata.com/resource/pubmed/grant/AI62261,
http://linkedlifedata.com/resource/pubmed/grant/DK007013-32,
http://linkedlifedata.com/resource/pubmed/grant/K24 AI069994-01A1,
http://linkedlifedata.com/resource/pubmed/grant/K24 AI069994-03,
http://linkedlifedata.com/resource/pubmed/grant/P30 A127763,
http://linkedlifedata.com/resource/pubmed/grant/P30 AI027763-18,
http://linkedlifedata.com/resource/pubmed/grant/P30 AI27763,
http://linkedlifedata.com/resource/pubmed/grant/P30 MH059037-14S1,
http://linkedlifedata.com/resource/pubmed/grant/P30 MH59037,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI040384-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI062261-05,
http://linkedlifedata.com/resource/pubmed/grant/T32 DK007013-32,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI068634,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI068634-04,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI068636-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI069501-04,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024131,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024131-04
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-12404116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-14624369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-14722271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-17003398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-17442709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-18461165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-18818774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-19265479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-7627622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-8132784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-8617980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-9171221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20565257-9400591
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1537-6613
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pubmed:author |
pubmed-author:BadleyAndrew DAD,
pubmed-author:BoschRonald JRJ,
pubmed-author:BrenGary DGD,
pubmed-author:BrenchleyJasonJ,
pubmed-author:CumminsNathan WNW,
pubmed-author:DeeksSteven GSG,
pubmed-author:DouekDanielD,
pubmed-author:LandayAlanA,
pubmed-author:LedermanMichael MMM,
pubmed-author:MartinJeffrey NJN,
pubmed-author:McGintyJohnJ,
pubmed-author:WeiJiangJ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
202
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-91
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20565257-Adult,
pubmed-meshheading:20565257-CD4 Lymphocyte Count,
pubmed-meshheading:20565257-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20565257-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20565257-Caspase 8,
pubmed-meshheading:20565257-Cross-Sectional Studies,
pubmed-meshheading:20565257-Female,
pubmed-meshheading:20565257-HIV,
pubmed-meshheading:20565257-HIV Infections,
pubmed-meshheading:20565257-Humans,
pubmed-meshheading:20565257-Longitudinal Studies,
pubmed-meshheading:20565257-Male,
pubmed-meshheading:20565257-Middle Aged,
pubmed-meshheading:20565257-Viral Load
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pubmed:year |
2010
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pubmed:articleTitle |
Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
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pubmed:affiliation |
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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