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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
Recent genome-wide association studies of lung cancer have shown that the CHRNA5-A3 region on chromosome 15q24-25.1 is strongly associated with an increased risk of lung cancer and nicotine dependence, and is thought to be associated with chronic obstructive pulmonary disease as well. However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-11994237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-12220364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-12530702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-15641418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-15947299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-17470739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-17942466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18385676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18385738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18385739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18957674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18957677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-18978134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-19010884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564069-3806354
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3458-62
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20564069-Female,
pubmed-meshheading:20564069-Genetic Loci,
pubmed-meshheading:20564069-Humans,
pubmed-meshheading:20564069-Lung Neoplasms,
pubmed-meshheading:20564069-Male,
pubmed-meshheading:20564069-Middle Aged,
pubmed-meshheading:20564069-Nerve Tissue Proteins,
pubmed-meshheading:20564069-Polymorphism, Single Nucleotide,
pubmed-meshheading:20564069-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:20564069-Pulmonary Emphysema,
pubmed-meshheading:20564069-Receptors, Nicotinic,
pubmed-meshheading:20564069-Risk,
pubmed-meshheading:20564069-Smoking,
pubmed-meshheading:20564069-Tobacco Use Disorder
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pubmed:year |
2010
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pubmed:articleTitle |
Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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