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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-10-12
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pubmed:abstractText |
The ATP-binding cassette transporter A1 (ABCA1) lipidates apolipoprotein (apo) A-I. The hypothesis that hepatocyte-specific ABCA1 overexpression results in high-density lipoprotein (HDL) dysfunction was evaluated by comparing the effects of murine ABCA1 (AdABCA1) and human apo A-I (AdA-I) transfer on lipoprotein profile, HDL function, and progression of atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP binding cassette transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/very low density lipoprotein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
376-85
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pubmed:meshHeading |
pubmed-meshheading:20562425-ATP-Binding Cassette Transporters,
pubmed-meshheading:20562425-Animals,
pubmed-meshheading:20562425-Apolipoprotein A-I,
pubmed-meshheading:20562425-Apolipoproteins B,
pubmed-meshheading:20562425-Apolipoproteins E,
pubmed-meshheading:20562425-Atherosclerosis,
pubmed-meshheading:20562425-Biological Transport,
pubmed-meshheading:20562425-Cholesterol, HDL,
pubmed-meshheading:20562425-Disease Models, Animal,
pubmed-meshheading:20562425-Endothelial Cells,
pubmed-meshheading:20562425-Female,
pubmed-meshheading:20562425-Gene Transfer Techniques,
pubmed-meshheading:20562425-Hepatocytes,
pubmed-meshheading:20562425-Lipoproteins, VLDL,
pubmed-meshheading:20562425-Male,
pubmed-meshheading:20562425-Mice,
pubmed-meshheading:20562425-Mice, Inbred C57BL,
pubmed-meshheading:20562425-Mice, Knockout,
pubmed-meshheading:20562425-Scavenger Receptors, Class B,
pubmed-meshheading:20562425-Stem Cells,
pubmed-meshheading:20562425-Time Factors,
pubmed-meshheading:20562425-Triglycerides,
pubmed-meshheading:20562425-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis.
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pubmed:affiliation |
Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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