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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0439851,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1552596,
umls-concept:C1552861,
umls-concept:C1704675,
umls-concept:C1706438,
umls-concept:C1947931,
umls-concept:C2698600
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pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-7-5
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|
pubmed:abstractText |
Accumulating evidence suggests that CD4 help is needed at the memory stage to mount effective secondary CD8 T cell responses. In this paper, we report that memory CD4 T cells can provide efficient help to memory CD8 T cells after interaction of the two lymphocytes with distinct dendritic cells. Provision of help to CD8 T cells required direct cell-cell contact and involved both IL-2 and CD40 ligation, within a CD4-CD8 T cell synapse. Thus, following antigenic interaction with APCs, activated memory CD4 and CD8 T cells appear to separate from their respective APCs before meeting each other for help provision, regardless of their Ag specificity. CD4 help for memory CD8 T cells therefore appears to be conditioned primarily not by Ag specificity but by activation status.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1550-6606
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1028-36
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pubmed:meshHeading |
pubmed-meshheading:20562265-Animals,
pubmed-meshheading:20562265-Antigen Presentation,
pubmed-meshheading:20562265-Antigens, CD40,
pubmed-meshheading:20562265-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20562265-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20562265-Carcinoma, Lewis Lung,
pubmed-meshheading:20562265-Cell Communication,
pubmed-meshheading:20562265-Cell Line, Tumor,
pubmed-meshheading:20562265-Cell Proliferation,
pubmed-meshheading:20562265-Coculture Techniques,
pubmed-meshheading:20562265-Cytotoxicity, Immunologic,
pubmed-meshheading:20562265-Dendritic Cells,
pubmed-meshheading:20562265-Female,
pubmed-meshheading:20562265-Flow Cytometry,
pubmed-meshheading:20562265-Granzymes,
pubmed-meshheading:20562265-Immunologic Memory,
pubmed-meshheading:20562265-Interleukin-2,
pubmed-meshheading:20562265-Lymphocyte Activation,
pubmed-meshheading:20562265-Major Histocompatibility Complex,
pubmed-meshheading:20562265-Male,
pubmed-meshheading:20562265-Mice,
pubmed-meshheading:20562265-Mice, Inbred C57BL,
pubmed-meshheading:20562265-Mice, Knockout
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pubmed:year |
2010
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pubmed:articleTitle |
Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale U-1012, Université Paris-Sud, Faculté de Médecine, 94276 Le Kremlin-Bicêtre, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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