Linked Life Data

20562063

Source:http://linkedlifedata.com/resource/pubmed/id/20562063

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-6-21
pubmed:abstractText
The success of first-line antiretroviral therapy can be challenged by the acquisition of primary drug resistance. Here we report a case where baseline genotypic resistance testing detected resistance conferring nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)-associated mutations, but no primary mutations for protease inhibitor (PI). Subsequent PI-based HAART with boosted saquinavir led to virological treatment success with persistently undetectable viral load. After treatment simplification from saquinavir to an atazanavir based PI-therapy and no change in backbone therapy rapid virological breakthrough occurred. Retrospective analysis displayed preexisting gag cleavage site mutations which may have reduced the genetic barrier in a clinical relevant manner in combination with the already existing NRTI resistance mutations. Alternatively, this effect could be explained with a different antiviral potency for the respective PIs used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0949-2321
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Transmission of human immunodeficiency virus I drug resistance - a case report. What are the clinical implications?
pubmed:affiliation
Department of General Internal Medicine, University of Bonn, Sigmund-Freud Strasse 25, 53105 Bonn, Germany. evrim.anadol@ukb.uni-bonn.de
pubmed:publicationType
Journal Article, Case Reports