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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-21
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pubmed:abstractText |
Age associated cognitive impairment is associated with low levels of IGF-1, oxidative stress, and neuronal loss in the hippocampus. Ames dwarf mice are long-lived animals that exhibit peripheral IGF-1 deficiency. Hippocampal-based spatial memory (a homolog of cognitive function) has not been evaluated in these long-living mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1872-6216
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
422-35
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pubmed:meshHeading |
pubmed-meshheading:20561541-Animals,
pubmed-meshheading:20561541-Cognition,
pubmed-meshheading:20561541-Cognition Disorders,
pubmed-meshheading:20561541-Female,
pubmed-meshheading:20561541-Gene Expression,
pubmed-meshheading:20561541-Hippocampus,
pubmed-meshheading:20561541-Insulin-Like Growth Factor I,
pubmed-meshheading:20561541-Kainic Acid,
pubmed-meshheading:20561541-Longevity,
pubmed-meshheading:20561541-Male,
pubmed-meshheading:20561541-Maze Learning,
pubmed-meshheading:20561541-Memory,
pubmed-meshheading:20561541-Mice,
pubmed-meshheading:20561541-Mice, Mutant Strains,
pubmed-meshheading:20561541-Neurodegenerative Diseases
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pubmed:year |
2010
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pubmed:articleTitle |
Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neurodegeneration.
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pubmed:affiliation |
Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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