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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2010-6-21
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pubmed:abstractText |
A convergent and high-yielding approach for the asymmetric synthesis of sulforaphane 2 and four analogues differently substituted at the sulfinyl sulfur has been developed. The key step of the synthesis is the diastereoselective synthesis of sulfinate ester 23-S(S), using the DAG (diacetone-D-glucofuranose)-methodology. The biological activity of these compounds as inductors of phase II detoxifying enzyme has been studied by determining their ability to activate the cytoprotective transcription factor Nrf2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1520-6904
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6002-9
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pubmed:meshHeading |
pubmed-meshheading:20560566-Animals,
pubmed-meshheading:20560566-Antineoplastic Agents,
pubmed-meshheading:20560566-Antioxidants,
pubmed-meshheading:20560566-Cell Line,
pubmed-meshheading:20560566-Cytoprotection,
pubmed-meshheading:20560566-Dose-Response Relationship, Drug,
pubmed-meshheading:20560566-Enzyme Induction,
pubmed-meshheading:20560566-Humans,
pubmed-meshheading:20560566-Metabolic Detoxication, Phase II,
pubmed-meshheading:20560566-NF-E2-Related Factor 2,
pubmed-meshheading:20560566-Rats,
pubmed-meshheading:20560566-Response Elements,
pubmed-meshheading:20560566-Stereoisomerism,
pubmed-meshheading:20560566-Sulfur,
pubmed-meshheading:20560566-Thiocyanates
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pubmed:year |
2009
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pubmed:articleTitle |
Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: asymmetric synthesis and biological activities.
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pubmed:affiliation |
Instituto de Investigaciones Químicas, C.S.I.C-Universidad de Sevilla, c/. Américo Vespucio, 49., Isla de la Cartuja, 41092 Sevilla, Spain. khiar@iiq.csic.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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