Linked Life Data

20559959

Source:http://linkedlifedata.com/resource/pubmed/id/20559959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-18
pubmed:abstractText
Multiple clinical trials have been performed to test the hypothesis that administration of bone-marrow-derived progenitor and stem cells (BMCs) may improve left-ventricular (LV) function following acute myocardial infarction (AMI). These studies have generally confirmed that cell therapy administration can be safely administered; however, consensus has not been reached on whether this approach results in an improvement in LV function or clinical outcomes. Although many of the published studies have been randomized, placebo-controlled trials, many important questions regarding patient selection, methodology and trial design still exist. To date, almost no information has been obtained in regard to optimal dosing and cell type, timing of administration and preferred method of delivery. As a result, current cell therapy administration for AMI finds itself at the crossroads. In this review we have highlighted some of the important questions that remain unanswered in the field of cell therapy after AMI. We believe that future cell therapy trials should attempt to incorporate these important issues in designing upcoming clinical trials in order for the field to move forward.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1937-5395
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-70
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Cell therapy for acute myocardial infarction--where do we go from here?
pubmed:affiliation
Cardiovascular Division, Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, University of Minnesota Medical School, Minneapolis, MN, USA. trave004@umn.edu
pubmed:publicationType
Journal Article, Review