| pubmed-article:2055946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2055946 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2055946 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2055946 | pubmed:dateCreated | 1991-7-26 | lld:pubmed |
| pubmed-article:2055946 | pubmed:abstractText | Downregulation of the c-myc gene in HL-60 cells is associated with growth inhibition and induction of differentiation. Previous studies have reported that the growth inhibitors TGF beta and TNF alpha downregulate c-myc mRNA levels, suggesting the possibility that these agents may exert some of their phenotypic effects via c-myc downregulation. Our study demonstrates that although both growth inhibitors produce a similar decrease in c-myc protein synthesis, TNF alpha produces a greater growth inhibition and differentiation induction in HL-60 cells. Combined addition of anti-myc oligomer with either growth inhibitor produces no additive effect. In fact, 4 microM anti-myc oligomer produces the same growth and differentiation effects as does 10 ng/ml TGF beta 1. We conclude that downregulation of c-myc expression represents a common mechanism of growth inhibition by TGF beta and TNF alpha, but that TNF alpha possesses an additional effect that is independent of c-myc expression. | lld:pubmed |
| pubmed-article:2055946 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2055946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2055946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2055946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2055946 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2055946 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:2055946 | pubmed:author | pubmed-author:HannS RSR | lld:pubmed |
| pubmed-article:2055946 | pubmed:author | pubmed-author:HoltJ TJT | lld:pubmed |
| pubmed-article:2055946 | pubmed:author | pubmed-author:SalhanyK EKE | lld:pubmed |
| pubmed-article:2055946 | pubmed:author | pubmed-author:Robinson-Beni... | lld:pubmed |
| pubmed-article:2055946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2055946 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:2055946 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:2055946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2055946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2055946 | pubmed:pagination | 188-95 | lld:pubmed |
| pubmed-article:2055946 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:meshHeading | pubmed-meshheading:2055946-... | lld:pubmed |
| pubmed-article:2055946 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2055946 | pubmed:articleTitle | Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGF beta and TNF alpha. | lld:pubmed |
| pubmed-article:2055946 | pubmed:affiliation | Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232. | lld:pubmed |
| pubmed-article:2055946 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2055946 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2055946 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2055946 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2055946 | lld:pubmed |
