Linked Life Data

20558857

Source:http://linkedlifedata.com/resource/pubmed/id/20558857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-6-18
pubmed:abstractText
We present an atypical case of Cushing's syndrome caused by ectopic adrenocorticotropic hormone (ACTH) secretion in a patient with a metastasised adenocarcinoma of the oesophagus. After chemotherapy and surgery the patient developed generalised oedema, hyperpigmentation and dysphagia. Laboratory tests showed hypokalaemia, normal urinary potassium, increased 24-hour urinary free cortisol excretion and serum ACTH within the normal reference range. The diagnosis of ACTH-dependent Cushing's syndrome was made, most probably caused by ectopic production of ACTH. In addition to combined chemotherapy, treatment with ketoconazole sufficiently reduced urinary cortisol excretion and relieved the symptoms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1872-9061
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Atypical Cushing's syndrome caused by ectopic ACTH secretion of an oesophageal adenocarcinoma.
pubmed:affiliation
Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands. j.m.baas@lumc.nl
pubmed:publicationType
Journal Article, Case Reports