| pubmed-article:20555027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20555027 | lifeskim:mentions | umls-concept:C0014272 | lld:lifeskim |
| pubmed-article:20555027 | lifeskim:mentions | umls-concept:C0081880 | lld:lifeskim |
| pubmed-article:20555027 | lifeskim:mentions | umls-concept:C0013470 | lld:lifeskim |
| pubmed-article:20555027 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:20555027 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20555027 | pubmed:dateCreated | 2010-7-27 | lld:pubmed |
| pubmed-article:20555027 | pubmed:abstractText | The physiological implication of C-type natriuretic peptide (CNP) including energy metabolism has not been elucidated, because of markedly short stature in CNP-null mice. In the present study we analyzed food intake and energy expenditure of CNP-null mice with chondrocyte-targeted CNP expression (CNP-Tg/Nppc(-/-) mice), in which marked skeletal dysplasia was rescued, to investigate the significance of CNP under minimal influences of skeletal phenotypes. In CNP-Tg/Nppc(-/-) mice, body weight and body fat ratio were reduced by 24% and 32%, respectively, at 20 wk of age, and decreases of blood glucose levels during insulin tolerance tests were 2-fold exaggerated at 17 wk of age, as compared with CNP-Tg/Nppc(+/+) mice. Urinary noradrenalin excretion of CNP-Tg/Nppc(-/-) mice was greater than that of CNP-Tg/Nppc(+/+) mice by 28%. In CNP-Tg/Nppc(-/-) mice, rectal temperature at 1600 h was higher by 1.1 C, and uncoupling protein-1 mRNA expression in the brown adipose tissue was 2-fold increased, which was canceled by propranolol administration, as compared with CNP-Tg/Nppc(+/+) mice. Oxygen consumption was significantly increased in CNP-Tg/Nppc(-/-) mice compared with that in CNP-Tg/Nppc(+/+) mice. Food intake of CNP-Tg/Nppc(-/-) mice upon ad libitum feeding and refeeding after 48 h starvation were reduced by 21% and 61%, respectively, as compared with CNP-Tg/Nppc(+/+) mice. This study unveiled a new aspect of CNP as a molecule regulating food intake and energy expenditure. Further analyses on precise mechanisms of CNP actions would lead to the better understanding of the significance of the CNP/guanylyl cyclase-B system in food intake and energy expenditure. | lld:pubmed |
| pubmed-article:20555027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20555027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20555027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20555027 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20555027 | pubmed:issn | 1945-7170 | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:NakaoKazuwaK | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:OhinataKousak... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:KatsuuraGoroG | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:TamuraNaohisa... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:YamadaNobukoN | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:FukunagaYasut... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:SoneMasakatsu... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:OyamadaNaofum... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:TauraDaisukeD | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:InuzukaMegumi... | lld:pubmed |
| pubmed-article:20555027 | pubmed:author | pubmed-author:SonoyamaTakuh... | lld:pubmed |
| pubmed-article:20555027 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20555027 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:20555027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20555027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20555027 | pubmed:pagination | 3633-42 | lld:pubmed |
| pubmed-article:20555027 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
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| pubmed-article:20555027 | pubmed:meshHeading | pubmed-meshheading:20555027... | lld:pubmed |
| pubmed-article:20555027 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20555027 | pubmed:articleTitle | C-type natriuretic peptide as a new regulator of food intake and energy expenditure. | lld:pubmed |
| pubmed-article:20555027 | pubmed:affiliation | Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan. | lld:pubmed |
| pubmed-article:20555027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20555027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:18159 | entrezgene:pubmed | pubmed-article:20555027 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20555027 | lld:entrezgene |
