Source:http://linkedlifedata.com/resource/pubmed/id/20555027
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-7-27
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| pubmed:abstractText |
The physiological implication of C-type natriuretic peptide (CNP) including energy metabolism has not been elucidated, because of markedly short stature in CNP-null mice. In the present study we analyzed food intake and energy expenditure of CNP-null mice with chondrocyte-targeted CNP expression (CNP-Tg/Nppc(-/-) mice), in which marked skeletal dysplasia was rescued, to investigate the significance of CNP under minimal influences of skeletal phenotypes. In CNP-Tg/Nppc(-/-) mice, body weight and body fat ratio were reduced by 24% and 32%, respectively, at 20 wk of age, and decreases of blood glucose levels during insulin tolerance tests were 2-fold exaggerated at 17 wk of age, as compared with CNP-Tg/Nppc(+/+) mice. Urinary noradrenalin excretion of CNP-Tg/Nppc(-/-) mice was greater than that of CNP-Tg/Nppc(+/+) mice by 28%. In CNP-Tg/Nppc(-/-) mice, rectal temperature at 1600 h was higher by 1.1 C, and uncoupling protein-1 mRNA expression in the brown adipose tissue was 2-fold increased, which was canceled by propranolol administration, as compared with CNP-Tg/Nppc(+/+) mice. Oxygen consumption was significantly increased in CNP-Tg/Nppc(-/-) mice compared with that in CNP-Tg/Nppc(+/+) mice. Food intake of CNP-Tg/Nppc(-/-) mice upon ad libitum feeding and refeeding after 48 h starvation were reduced by 21% and 61%, respectively, as compared with CNP-Tg/Nppc(+/+) mice. This study unveiled a new aspect of CNP as a molecule regulating food intake and energy expenditure. Further analyses on precise mechanisms of CNP actions would lead to the better understanding of the significance of the CNP/guanylyl cyclase-B system in food intake and energy expenditure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agouti-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Agrp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Ppargc1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1945-7170
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| pubmed:author |
pubmed-author:FukunagaYasutomoY,
pubmed-author:InuzukaMegumiM,
pubmed-author:KatsuuraGoroG,
pubmed-author:NakaoKazuwaK,
pubmed-author:OhinataKousakuK,
pubmed-author:OyamadaNaofumiN,
pubmed-author:SoneMasakatsuM,
pubmed-author:SonoyamaTakuhiroT,
pubmed-author:TamuraNaohisaN,
pubmed-author:TauraDaisukeD,
pubmed-author:YamadaNobukoN
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| pubmed:issnType |
Electronic
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| pubmed:volume |
151
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3633-42
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| pubmed:dateRevised |
2011-8-3
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| pubmed:meshHeading |
pubmed-meshheading:20555027-Agouti-Related Protein,
pubmed-meshheading:20555027-Animals,
pubmed-meshheading:20555027-Appetite Regulation,
pubmed-meshheading:20555027-Body Temperature,
pubmed-meshheading:20555027-Chondrocytes,
pubmed-meshheading:20555027-Energy Metabolism,
pubmed-meshheading:20555027-Gene Expression Regulation,
pubmed-meshheading:20555027-Guanylate Cyclase,
pubmed-meshheading:20555027-Injections, Intraventricular,
pubmed-meshheading:20555027-Male,
pubmed-meshheading:20555027-Mice,
pubmed-meshheading:20555027-Mice, Inbred C57BL,
pubmed-meshheading:20555027-Mice, Transgenic,
pubmed-meshheading:20555027-Natriuretic Peptide, C-Type,
pubmed-meshheading:20555027-Neuropeptide Y,
pubmed-meshheading:20555027-Norepinephrine,
pubmed-meshheading:20555027-Organ Specificity,
pubmed-meshheading:20555027-PPAR gamma,
pubmed-meshheading:20555027-Tissue Distribution,
pubmed-meshheading:20555027-Trans-Activators
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| pubmed:year |
2010
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| pubmed:articleTitle |
C-type natriuretic peptide as a new regulator of food intake and energy expenditure.
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| pubmed:affiliation |
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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