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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-7-21
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pubmed:abstractText |
Patients with glioblastoma multiforme, the most aggressive form of glioma, have a median survival of approximately 12 months. Calcium (Ca(2+)) signaling plays an important role in cell proliferation, and some members of the Ca(2+)-permeable transient receptor potential canonical (TRPC) family of channel proteins have demonstrated a role in the proliferation of many types of cancer cells. In this study, we investigated the role of TRPC6 in cell cycle progression and in the development of human glioma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1460-2105
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pubmed:author |
pubmed-author:ChengJuJ,
pubmed-author:DongBinB,
pubmed-author:HILDWW,
pubmed-author:HeZhuohaoZ,
pubmed-author:JinYeningY,
pubmed-author:LuDongliangD,
pubmed-author:TuftRR,
pubmed-author:WangYizhengY,
pubmed-author:XuYinghuiY,
pubmed-author:YaoHailanH,
pubmed-author:ZhouKechunK
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1052-68
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pubmed:meshHeading |
pubmed-meshheading:20554944-Adenoviridae,
pubmed-meshheading:20554944-Animals,
pubmed-meshheading:20554944-Base Sequence,
pubmed-meshheading:20554944-Brain Neoplasms,
pubmed-meshheading:20554944-Cell Division,
pubmed-meshheading:20554944-Cell Line, Tumor,
pubmed-meshheading:20554944-Cell Transformation, Neoplastic,
pubmed-meshheading:20554944-Disease Models, Animal,
pubmed-meshheading:20554944-Flow Cytometry,
pubmed-meshheading:20554944-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:20554944-G2 Phase,
pubmed-meshheading:20554944-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20554944-Genetic Vectors,
pubmed-meshheading:20554944-Glioma,
pubmed-meshheading:20554944-Humans,
pubmed-meshheading:20554944-Immunoblotting,
pubmed-meshheading:20554944-Immunohistochemistry,
pubmed-meshheading:20554944-In Situ Hybridization,
pubmed-meshheading:20554944-Lentivirus,
pubmed-meshheading:20554944-Mice,
pubmed-meshheading:20554944-Molecular Sequence Data,
pubmed-meshheading:20554944-Phenotype,
pubmed-meshheading:20554944-RNA, Messenger,
pubmed-meshheading:20554944-RNA, Small Interfering,
pubmed-meshheading:20554944-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20554944-TRPC Cation Channels,
pubmed-meshheading:20554944-Transplantation, Heterologous,
pubmed-meshheading:20554944-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Essential role of TRPC6 channels in G2/M phase transition and development of human glioma.
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pubmed:affiliation |
Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institute for Biological Sciences, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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