Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2010-6-17
pubmed:abstractText
Oleoylethanolamide (OEA) is a biologically active lipid amide that is released by small-intestinal enterocytes during the absorption of dietary fat and inhibits feeding by engaging the nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Previous studies have shown that the anorexic effects of systemically administered OEA require the activation of sensory afferents of the vagus nerve. The central circuits involved in mediating OEA-induced hypophagia remain unknown. In the present study, we report the results of in situ hybridization and immunohistochemistry experiments in rats and mice, which show that systemic injections of OEA (5-10 mg kg(-1), intraperitoneal) enhance expression of the neuropeptide oxytocin in magnocellular neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. No such effect is observed with other hypothalamic neuropeptides, including vasopressin, thyrotropin-releasing hormone and pro-opiomelanocortin. The increase in oxytocin expression elicited by OEA was absent in mutant PPAR-alpha-null mice. Pharmacological blockade of oxytocin receptors in the brain by intracerebroventricular infusion of the selective oxytocin antagonist, L-368,899, prevented the anorexic effects of OEA. The results suggest that OEA suppresses feeding by activating central oxytocin transmission.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8096-101
pubmed:dateRevised
2011-4-21
pubmed:meshHeading
pubmed-meshheading:20554860-Animals, pubmed-meshheading:20554860-Bornanes, pubmed-meshheading:20554860-Dose-Response Relationship, Drug, pubmed-meshheading:20554860-Drug Administration Routes, pubmed-meshheading:20554860-Gene Expression Regulation, pubmed-meshheading:20554860-Male, pubmed-meshheading:20554860-Mice, pubmed-meshheading:20554860-Mice, Inbred C57BL, pubmed-meshheading:20554860-Mice, Knockout, pubmed-meshheading:20554860-Oleic Acids, pubmed-meshheading:20554860-Oxytocin, pubmed-meshheading:20554860-PPAR alpha, pubmed-meshheading:20554860-Paraventricular Hypothalamic Nucleus, pubmed-meshheading:20554860-Piperazines, pubmed-meshheading:20554860-RNA, Messenger, pubmed-meshheading:20554860-Rats, pubmed-meshheading:20554860-Rats, Wistar, pubmed-meshheading:20554860-Supraoptic Nucleus
pubmed:year
2010
pubmed:articleTitle
The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin.
pubmed:affiliation
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, 00185 Rome, Italy. piomelli@uci.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural