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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-7-2
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pubmed:abstractText |
Diabodies are noncovalent dimers of single-chain antibody fragments that retain the avidity of intact IgG but have more favorable blood clearance than intact IgG. Radiometals offer a wide range of half-lives and emissions for matching imaging and therapy requirements and provide facile labeling of chelate-antibody conjugates. However, because of their high retention and metabolism in the kidney, the use of radiometal-labeled diabodies can be problematic for both imaging and therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1535-5667
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pubmed:author |
pubmed-author:AndersonAnne-LineAL,
pubmed-author:BadingJames RJR,
pubmed-author:CavetMeganM,
pubmed-author:ColcherDavidD,
pubmed-author:CrowDesireeD,
pubmed-author:HudsonPeter JPJ,
pubmed-author:JooFF,
pubmed-author:PokuErasmusE,
pubmed-author:RaubitschekAndrewA,
pubmed-author:SandersPaulP,
pubmed-author:ShivelyJohn EJE,
pubmed-author:TamvakisDebraD,
pubmed-author:TurattiFabioF,
pubmed-author:WilliamsLawrence ELE,
pubmed-author:YazakiPaul JPJ
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1139-46
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pubmed:meshHeading |
pubmed-meshheading:20554731-Animals,
pubmed-meshheading:20554731-Chromatography, Gel,
pubmed-meshheading:20554731-Cloning, Molecular,
pubmed-meshheading:20554731-Copper Radioisotopes,
pubmed-meshheading:20554731-Immunochemistry,
pubmed-meshheading:20554731-Immunoglobulin G,
pubmed-meshheading:20554731-Isoelectric Focusing,
pubmed-meshheading:20554731-Kidney,
pubmed-meshheading:20554731-Mass Spectrometry,
pubmed-meshheading:20554731-Mice,
pubmed-meshheading:20554731-Mice, Nude,
pubmed-meshheading:20554731-Neoplasm Transplantation,
pubmed-meshheading:20554731-Neoplasms,
pubmed-meshheading:20554731-Peptide Fragments,
pubmed-meshheading:20554731-Polyethylene Glycols,
pubmed-meshheading:20554731-Positron-Emission Tomography,
pubmed-meshheading:20554731-Radiopharmaceuticals,
pubmed-meshheading:20554731-Tissue Distribution,
pubmed-meshheading:20554731-Ultracentrifugation
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pubmed:year |
2010
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pubmed:articleTitle |
Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET.
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pubmed:affiliation |
Department of Immunology, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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