|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-7-2
|
|
pubmed:abstractText |
Hypoxic tumor cells are resistant to radiotherapy and various chemotherapeutic agents. The pretherapeutic assessment of intratumoral hypoxia may allow selection of patients for intensified treatment regimens. Carbonic anhydrase IX (CAIX) is an endogenous hypoxia-related protein involved in pH regulation and is upregulated in many tumor types. Radionuclide imaging using a monoclonal antibody against CAIX, such as cG250, may allow noninvasive PET of hypoxia in these tumor types. The aims of this study were to investigate whether (89)Zr-labeled cG250-F(ab')(2) allowed visualization of tumor hypoxia using small-animal PET and whether the tracer showed spatial correlation to the microscopic distribution of CAIX-expressing cells in a human head and neck xenograft tumor model.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/G250 monoclonal antibody,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fab Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Sensitizing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Zirconium,
http://linkedlifedata.com/resource/pubmed/chemical/pimonidazole
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1535-5667
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1076-83
|
|
pubmed:dateRevised |
2011-7-29
|
|
pubmed:meshHeading |
pubmed-meshheading:20554724-Animals,
pubmed-meshheading:20554724-Anoxia,
pubmed-meshheading:20554724-Antibodies, Monoclonal,
pubmed-meshheading:20554724-Autoradiography,
pubmed-meshheading:20554724-Carbonic Anhydrase Inhibitors,
pubmed-meshheading:20554724-Head and Neck Neoplasms,
pubmed-meshheading:20554724-Image Processing, Computer-Assisted,
pubmed-meshheading:20554724-Immunoglobulin Fab Fragments,
pubmed-meshheading:20554724-Immunoglobulin G,
pubmed-meshheading:20554724-Immunohistochemistry,
pubmed-meshheading:20554724-Isotope Labeling,
pubmed-meshheading:20554724-Mice,
pubmed-meshheading:20554724-Mice, Inbred BALB C,
pubmed-meshheading:20554724-Nitroimidazoles,
pubmed-meshheading:20554724-Organometallic Compounds,
pubmed-meshheading:20554724-Positron-Emission Tomography,
pubmed-meshheading:20554724-Quality Control,
pubmed-meshheading:20554724-Radiation-Sensitizing Agents,
pubmed-meshheading:20554724-Radiopharmaceuticals,
pubmed-meshheading:20554724-Tissue Distribution,
pubmed-meshheading:20554724-Xenograft Model Antitumor Assays,
pubmed-meshheading:20554724-Zirconium
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
|
|
pubmed:affiliation |
Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. b.hoeben@rther.umcn.nl
|
|
pubmed:publicationType |
Journal Article
|
