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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-8-17
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pubmed:abstractText |
Natural killer (NK) cells play an important role in the immune response against virus infection. Interferon (IFN)-alpha, an essential component in therapy against hepatitis C virus (HCV) infection, regulates NK cell function. However, it remains obscure how chronic HCV infection (CHC) modifies intracellular IFN-alpha signaling in NK cells. We investigated IFN-alpha signaling in NK cells in patients with CHC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
424-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20554341-Adult,
pubmed-meshheading:20554341-Aged,
pubmed-meshheading:20554341-Case-Control Studies,
pubmed-meshheading:20554341-Female,
pubmed-meshheading:20554341-Hepatitis C, Chronic,
pubmed-meshheading:20554341-Humans,
pubmed-meshheading:20554341-Interferon-alpha,
pubmed-meshheading:20554341-Interferon-gamma,
pubmed-meshheading:20554341-Interleukin-12,
pubmed-meshheading:20554341-Killer Cells, Natural,
pubmed-meshheading:20554341-Male,
pubmed-meshheading:20554341-Middle Aged,
pubmed-meshheading:20554341-Phosphorylation,
pubmed-meshheading:20554341-RNA, Messenger,
pubmed-meshheading:20554341-Recombinant Proteins,
pubmed-meshheading:20554341-STAT1 Transcription Factor,
pubmed-meshheading:20554341-STAT4 Transcription Factor,
pubmed-meshheading:20554341-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Altered interferon-alpha-signaling in natural killer cells from patients with chronic hepatitis C virus infection.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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