Linked Life Data

20554163

Source:http://linkedlifedata.com/resource/pubmed/id/20554163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-7-12
pubmed:abstractText
The activity of ceftobiprole and comparator agents was evaluated against a collection of 880 isolates, comprising 200 meticillin-susceptible Staphylococcus aureus, 200 meticillin-resistant S. aureus, 180 coagulase-negative staphylococci blood isolates, 100 Streptococcuspneumoniae and 200 macrolide-resistant beta-haemolytic streptococci (100 Streptococcus pyogenes and 100 Streptococcus agalactiae). Ceftobiprole showed excellent activity against staphylococci (minimum inhibitory concentrations <or=4 microg/mL), irrespective of their susceptibility to other agents such as oxacillin, linezolid or glycopeptides. Ceftobiprole was also highly active against penicillin-resistant S. pneumoniae and macrolide-resistant beta-haemolytic streptococci, inhibiting 99.6% of all streptococci tested at <or=0.5 microg/mL. Based on these results, ceftobiprole appears to be a promising agent for the treatment of infections caused by multidrug-resistant Gram-positive pathogens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1872-7913
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Comparative in vitro activity of ceftobiprole against Gram-positive cocci.
pubmed:affiliation
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, 28040 Madrid, Spain. cbetriu.hcsc@salud.madrid.org
pubmed:publicationType
Journal Article, Comparative Study