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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-8-13
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pubmed:abstractText |
In most patients with systemic mastocytosis (SM), including aggressive SM (ASM) and mast cell (MC) leukemia (MCL), neoplastic cells express the oncogenic KIT mutation D816V, which confers resistance to imatinib. Cladribine (2CdA) is a nucleoside analog that has been introduced as a promising agent for treatment of advanced SM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1873-2399
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pubmed:author |
pubmed-author:BöhmAlexandraA,
pubmed-author:BlattKatharinaK,
pubmed-author:GleixnerKaroline VKV,
pubmed-author:HerrmannHaraldH,
pubmed-author:PehambergerHubertH,
pubmed-author:PeterBarbaraB,
pubmed-author:PicklWinfried FWF,
pubmed-author:RabitschWernerW,
pubmed-author:SchernthanerGerit-HolgerGH,
pubmed-author:SchuchKarinaK,
pubmed-author:SonneckKarolineK,
pubmed-author:SperrWolfgang RWR,
pubmed-author:ValentPeterP
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
744-55
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pubmed:meshHeading |
pubmed-meshheading:20553795-Adult,
pubmed-meshheading:20553795-Aged,
pubmed-meshheading:20553795-Amino Acid Substitution,
pubmed-meshheading:20553795-Antineoplastic Agents,
pubmed-meshheading:20553795-Apoptosis,
pubmed-meshheading:20553795-Caspases,
pubmed-meshheading:20553795-Cell Line, Tumor,
pubmed-meshheading:20553795-Cladribine,
pubmed-meshheading:20553795-Drug Resistance, Neoplasm,
pubmed-meshheading:20553795-Female,
pubmed-meshheading:20553795-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20553795-Humans,
pubmed-meshheading:20553795-Male,
pubmed-meshheading:20553795-Mast Cells,
pubmed-meshheading:20553795-Mastocytosis, Systemic,
pubmed-meshheading:20553795-Middle Aged,
pubmed-meshheading:20553795-Mutation, Missense,
pubmed-meshheading:20553795-Piperazines,
pubmed-meshheading:20553795-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:20553795-Pyrimidines,
pubmed-meshheading:20553795-Tryptases
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pubmed:year |
2010
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pubmed:articleTitle |
In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V.
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pubmed:affiliation |
Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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