Linked Life Data

20553404

Source:http://linkedlifedata.com/resource/pubmed/id/20553404

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-11-5
pubmed:abstractText
A new 5,10,15,20-tetra-(phenoxy-3-carbonyl-1-amino-naphthyl)-porphyrin was prepared by an isocyanate condensation reaction and its photophysical properties fully evaluated, both in terms of photostability and singlet oxygen production. It shows considerably enhanced photostability when compared with the parent 5,10,15,20-tetra-(3-hydroxy-phenyl)-porphyrin, with the photodegradation quantum yields for T(NAF)PP and T(OH)PP being 4.65×10(-4) and 5.19×10(-3) , respectively. Its photodynamic effect in human carcinoma HT-29 cells was evaluated. The new porphyrin showed good properties as a sensitizer in photodynamic therapy with an in vitro cytotoxicity IC(50) value of 6.80?g mL(-1) for a 24h incubation. In addition to the potential of this compound, the synthetic route used provides possibilities of extension to a wide range of new sensitizers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1751-1097
pubmed:author
pubmed:copyrightInfo
© 2010 The Authors. Journal Compilation. The American Society of Photobiology.
pubmed:issnType
Electronic
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1147-53
pubmed:meshHeading
pubmed:articleTitle
A new nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a potential sensitizer for photodynamic therapy.
pubmed:affiliation
Departamento de Química, FCTUC, Universidade de Coimbra, Coimbra, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't