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pubmed-article:20553380pubmed:abstractTextThe metabolism of estrogen contained within hormone replacement therapy (HRT) is influenced by the route of administration, and this may affect the risk of venous thromboembolism. Thrombin generation, a global coagulation assay, is a marker of hypercoagulability and is of potential use in determining the thrombotic risk associated with particular HRT administration routes.lld:pubmed
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pubmed-article:20553380pubmed:articleTitleThe effect of estrone on thrombin generation may explain the different thrombotic risk between oral and transdermal hormone replacement therapy.lld:pubmed
pubmed-article:20553380pubmed:affiliationKing's Thrombosis Centre, King's College Hospital NHS Foundation Trust, London, UK. catherine.bagot@ggc.scot.nhs.uklld:pubmed
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