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rdf:type |
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lifeskim:mentions |
umls-concept:C0007292,
umls-concept:C0017262,
umls-concept:C0086045,
umls-concept:C0108082,
umls-concept:C0178719,
umls-concept:C0185117,
umls-concept:C0392756,
umls-concept:C0599894,
umls-concept:C0806036,
umls-concept:C1101610,
umls-concept:C1998811,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2011-9-21
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|
pubmed:abstractText |
What’s known on the subject? and What does the study add? Experimental data have shown that VDR overexpression in the duodenum and kidney cortex is a biological characteristic of genetic hypercalciuric stone-forming rats (GHS rat), and a link between idiopathic calcium stone formation and the microstatellite marker D12S339 (near the VDR locus) has been proven in humans. Our study shows that VDR can positively regulate the mRNA and protein expression of TRPV5, calbindin-D28k and PMCA1b in NRK cell lines. VDR knockdown results in a decrease in intracellular Ca²? concentration in NRK cell lines. The effect of the elevated VDR level in the kidney on hypercalciuria and the underlying mechanisms need to be further addressed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-410X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1314-9
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pubmed:meshHeading |
pubmed-meshheading:20553254-Adenoviridae,
pubmed-meshheading:20553254-Animals,
pubmed-meshheading:20553254-Blotting, Western,
pubmed-meshheading:20553254-Calcium,
pubmed-meshheading:20553254-Calcium Channels,
pubmed-meshheading:20553254-Cell Line,
pubmed-meshheading:20553254-Disease Models, Animal,
pubmed-meshheading:20553254-Gene Expression Regulation,
pubmed-meshheading:20553254-Gene Targeting,
pubmed-meshheading:20553254-Hypercapnia,
pubmed-meshheading:20553254-Intracellular Fluid,
pubmed-meshheading:20553254-Kidney Cortex,
pubmed-meshheading:20553254-MicroRNAs,
pubmed-meshheading:20553254-Microscopy, Confocal,
pubmed-meshheading:20553254-Plasma Membrane Calcium-Transporting ATPases,
pubmed-meshheading:20553254-RNA, Viral,
pubmed-meshheading:20553254-Rats,
pubmed-meshheading:20553254-Receptors, Calcitriol,
pubmed-meshheading:20553254-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20553254-Urothelium
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pubmed:year |
2011
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pubmed:articleTitle |
Adenovirus-delivered microRNA targeting the vitamin D receptor reduces intracellular Ca²? concentrations by regulating the expression of Ca²?-transport proteins in renal epithelial cells.
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pubmed:affiliation |
Department of Urology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, HuBei, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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