Linked Life Data

20553086

Source:http://linkedlifedata.com/resource/pubmed/id/20553086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-6-17
pubmed:abstractText
The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumor-free tissues. In the present study, we investigated the association between serum SOD activity and the risk of lung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study, with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baseline and stored at -80 degrees C until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lung cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second, third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI: 0.30-1.07), 1.16 ( 0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORs of 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, we found no significant association between serum SOD level and the risk of deaths from lung cancer in the present study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1513-7368
pubmed:author
pubmed:issnType
Print
pubmed:volume
10 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Relationship between serum levels of superoxide dismutase activity and subsequent risk of lung cancer mortality: Findings from a nested case-control study within the Japan Collaborative Cohort Study.
pubmed:affiliation
Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan. ptrminh@med.uoeh-u.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study