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pubmed-article:2055242pubmed:abstractTextNeuropeptide Y (NPY) (50-1000 nM) failed to modify basal or K(+)-stimulated Ca2+ influx in cortical or hippocampal synaptosomes from rat brain, whereas the voltage-sensitive Ca2+ channel (VSCC) blocker Cd2+ (50 microM) caused major inhibition. In cortical synaptosomes from chicken brain NPY (1.0 microM) failed to modify, whereas omega-conotoxin GV1A (0.1 microM) markedly inhibited Ca2+ influx. NPY does not appear to modify synaptosomal Ca2+ influx, however it may still affect VSCCs spatially distinct or 'upstream' from the nerve terminals.lld:pubmed
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pubmed-article:2055242pubmed:articleTitleThe effect of neuropeptide Y on voltage-sensitive Ca2+ channels.lld:pubmed
pubmed-article:2055242pubmed:affiliationPharmacology and Therapeutics, Defence Research Establishment Suffield, Alberta, Canada.lld:pubmed
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