rdf:type |
|
lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0024554,
umls-concept:C0025803,
umls-concept:C0033572,
umls-concept:C0034715,
umls-concept:C0039601,
umls-concept:C0043481,
umls-concept:C0205263,
umls-concept:C0596263,
umls-concept:C1280500,
umls-concept:C1516463
|
pubmed:issue |
4
|
pubmed:dateCreated |
2011-3-14
|
pubmed:abstractText |
Zinc is an important micronutrient involved in structural and regulatory functions in mammalian cells. It inhibits proliferation of both androgen-dependent and -independent prostate cancer in vitro. However, no report is available on the chemopreventive role of zinc on prostate cancer initiation in in vivo model. The main purpose of this study was to assess the chemopreventive effects of zinc on prostate carcinogenesis induced by a single dose of N-methyl-N-nitrosourea (MNU) and continuous testosterone administration in Sprague-Dawley rats.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1432-1335
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
137
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
677-86
|
pubmed:meshHeading |
pubmed-meshheading:20552224-Acid Phosphatase,
pubmed-meshheading:20552224-Animals,
pubmed-meshheading:20552224-Anticarcinogenic Agents,
pubmed-meshheading:20552224-Body Weight,
pubmed-meshheading:20552224-Lipid Peroxidation,
pubmed-meshheading:20552224-Male,
pubmed-meshheading:20552224-Methylnitrosourea,
pubmed-meshheading:20552224-Organ Size,
pubmed-meshheading:20552224-Prostatic Neoplasms,
pubmed-meshheading:20552224-Rats,
pubmed-meshheading:20552224-Rats, Sprague-Dawley,
pubmed-meshheading:20552224-Testosterone,
pubmed-meshheading:20552224-Tumor Suppressor Protein p53,
pubmed-meshheading:20552224-Zinc,
pubmed-meshheading:20552224-bcl-X Protein
|
pubmed:year |
2011
|
pubmed:articleTitle |
Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats.
|
pubmed:affiliation |
Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamilnadu 600113, India.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|