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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-17
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pubmed:abstractText |
Despite enormous advancements in our comprehension of molecular mechanisms governing hematopoietic stem cells (HSCs) engraftment in the bone marrow, current clinical protocols of intravenous (IV) transplantation suffer from a relatively low seeding efficiency. To solve this problem, intrabone (IB) injection of HSCs has been proposed. However, the mechanisms underlying the benefit provided by this procedure remain unknown. This study aims to evaluate the effect of IB on HSCs trafficking and homing features in the living rat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-2399
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pubmed:author |
pubmed-author:CassanelliClaraC,
pubmed-author:CurtiGiovannaG,
pubmed-author:FrassoniFrancescoF,
pubmed-author:MariniCeciliaC,
pubmed-author:MassolloMichelaM,
pubmed-author:MorbelliSilviaS,
pubmed-author:PintoValeriaV,
pubmed-author:PodestàMarinaM,
pubmed-author:SambucetiGianmarioG,
pubmed-author:UbezioGianlucaG,
pubmed-author:UccelliAntonioA
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pubmed:copyrightInfo |
Copyright © 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
968-77
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pubmed:meshHeading |
pubmed-meshheading:20550953-Animals,
pubmed-meshheading:20550953-Antigens, Thy-1,
pubmed-meshheading:20550953-Bone Marrow,
pubmed-meshheading:20550953-Bone and Bones,
pubmed-meshheading:20550953-Cell Proliferation,
pubmed-meshheading:20550953-Forelimb,
pubmed-meshheading:20550953-Hematopoiesis,
pubmed-meshheading:20550953-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:20550953-Hematopoietic Stem Cells,
pubmed-meshheading:20550953-Injections, Intravenous,
pubmed-meshheading:20550953-Liver,
pubmed-meshheading:20550953-Lung,
pubmed-meshheading:20550953-Lymph Nodes,
pubmed-meshheading:20550953-Male,
pubmed-meshheading:20550953-Myocardium,
pubmed-meshheading:20550953-Rats,
pubmed-meshheading:20550953-Rats, Inbred Lew,
pubmed-meshheading:20550953-Spleen,
pubmed-meshheading:20550953-Technetium Tc 99m Exametazime
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pubmed:year |
2010
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pubmed:articleTitle |
Contact with the bone marrow microenvironment readdresses the fate of transplanted hematopoietic stem cells.
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pubmed:affiliation |
Nuclear Medicine, University of Genoa, Azienda Ospedaliera San Martino, Genoa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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