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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-29
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pubmed:abstractText |
Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed ductal-like cytoplasmic MUC1 staining, but were negative for MUC2 and other mucin gene markers. In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm. The findings suggest that the presence of extracellular mucin does not exclude a diagnosis of lobular carcinoma, and the morphologic and molecular characteristics of lobular and ductal carcinomas are more complex than previously appreciated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-10219016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-10424790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-10797261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-10861509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-10963602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11169514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11179484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11190811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11293901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11391575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-11553815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-12829800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-15034139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-15976813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-16904320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-170320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-17172726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-17325485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-17721269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-17873114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-18490921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-19294003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-19490472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-19877120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-19970575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-208954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-2851305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-7260850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-8256859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-8730100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-9139698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-9355973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550696-9581847
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Catenins,
http://linkedlifedata.com/resource/pubmed/chemical/HER2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MUC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/delta catenin
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pubmed:status |
MEDLINE
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pubmed:issn |
1746-1596
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36
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pubmed:meshHeading |
pubmed-meshheading:20550696-Adenocarcinoma, Mucinous,
pubmed-meshheading:20550696-Aged,
pubmed-meshheading:20550696-Biopsy,
pubmed-meshheading:20550696-Breast Neoplasms,
pubmed-meshheading:20550696-Cadherins,
pubmed-meshheading:20550696-Carcinoma, Lobular,
pubmed-meshheading:20550696-Catenins,
pubmed-meshheading:20550696-Female,
pubmed-meshheading:20550696-Humans,
pubmed-meshheading:20550696-Immunohistochemistry,
pubmed-meshheading:20550696-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20550696-Mastectomy, Segmental,
pubmed-meshheading:20550696-Mucin-1,
pubmed-meshheading:20550696-Neoplasm Invasiveness,
pubmed-meshheading:20550696-Receptor, erbB-2,
pubmed-meshheading:20550696-Tissue Array Analysis,
pubmed-meshheading:20550696-Tumor Markers, Biological,
pubmed-meshheading:20550696-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies.
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pubmed:affiliation |
Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA. yuj@upmc.edu
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pubmed:publicationType |
Journal Article,
Case Reports
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