Source:http://linkedlifedata.com/resource/pubmed/id/20549286
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-12-14
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| pubmed:abstractText |
The aim of this study was to confirm the effect of implementing a hospital-wide project for appropriate use of antimicrobial prophylaxis (AMP) to reduce the rate of antibiotic-resistant organisms. Fifteen different manuals for each surgical department have been simultaneously implemented since February 2007. Compliance rate was compared between pre- and postintervention periods (3 months for each period). As an effect of this intervention, we analyzed changes in the rates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus among organisms isolated postoperatively. The number of operations was 1,627 in both periods. Among patients whose surgeries were longer than 3 h in duration, 75% received an additional intraoperative antimicrobial dose in the postintervention period and 23% in the preintervention period (P < 0.001). Although most patients received postoperative AMP with an interval of q12 h in the preintervention period, 63% of the patients received AMP with an interval of q8 h in the postintervention period. The duration of AMP use was reduced from 2.4 ± 1.9 to 1.6 ± 1.5 days (P < 0.001). Forty-seven percent of patients discontinued AMP within 24 h and 81% within 48 h. Isolation rates of P. aeruginosa among all gram-negative organisms significantly decreased from 13% (68/538 patients) to 7.3% (37/509 patients) (P = 0.004). Execution of a hospital-wide project to promote the appropriate use of AMP, including shortening the duration of AMP use, was useful to decrease the rate of P. aeruginosa isolated postoperatively.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1437-7780
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
418-23
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| pubmed:meshHeading |
pubmed-meshheading:20549286-Anti-Bacterial Agents,
pubmed-meshheading:20549286-Antibiotic Prophylaxis,
pubmed-meshheading:20549286-Drug Resistance, Bacterial,
pubmed-meshheading:20549286-Guideline Adherence,
pubmed-meshheading:20549286-Humans,
pubmed-meshheading:20549286-Methicillin-Resistant Staphylococcus aureus,
pubmed-meshheading:20549286-Physician's Practice Patterns,
pubmed-meshheading:20549286-Practice Guidelines as Topic,
pubmed-meshheading:20549286-Program Evaluation,
pubmed-meshheading:20549286-Pseudomonas Infections,
pubmed-meshheading:20549286-Pseudomonas aeruginosa,
pubmed-meshheading:20549286-Staphylococcal Infections,
pubmed-meshheading:20549286-Surgery Department, Hospital,
pubmed-meshheading:20549286-Surgical Wound Infection
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| pubmed:year |
2010
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| pubmed:articleTitle |
Implementation of a hospital-wide project for appropriate antimicrobial prophylaxis.
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| pubmed:affiliation |
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. yktabu@hyo-med.ac.jp
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| pubmed:publicationType |
Journal Article
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