|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-6-15
|
|
pubmed:abstractText |
Monocyte-derived macrophages critically perpetuate inflammatory responses after liver injury as a prerequisite for organ fibrosis. Experimental murine models identified an essential role for the CCR2-dependent infiltration of classical Gr1/Ly6C(+) monocytes in hepatic fibrosis. Moreover, the monocyte-related chemokine receptors CCR1 and CCR5 were recently recognized as important fibrosis modulators in mice. In humans, monocytes consist of classical CD14(+)CD16(-) and non-classical CD14(+)CD16(+) cells. We aimed at investigating the relevance of monocyte subpopulations for human liver fibrosis, and hypothesized that 'non-classical' monocytes critically exert inflammatory as well as profibrogenic functions in patients during liver disease progression.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-12663236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-12829440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-12871639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-12871640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-14517792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-15630444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-15633130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-15664244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-15884116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-16322748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-16415174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-16762000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-16920499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17135573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17200718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17236120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17328986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17332881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17364026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17415633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17484886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17525265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17690256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-17952090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19072358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19132917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19359521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19441102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19534673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19545363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19554540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19603542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19827165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-19965649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-8188183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-8781341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20548789-9466568
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
pubmed-author:GasslerNikolausN,
pubmed-author:HellerbrandClausC,
pubmed-author:LueddeTomT,
pubmed-author:NattermannJacobJ,
pubmed-author:SeidlerSebastianS,
pubmed-author:TackeFrankF,
pubmed-author:TischendorfJens J WJJ,
pubmed-author:TrautweinChristianC,
pubmed-author:WeiskirchenRalfR,
pubmed-author:ZerneckeAlmaA,
pubmed-author:ZimmermannHenning WHW
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e11049
|
|
pubmed:dateRevised |
2010-9-28
|
|
pubmed:meshHeading |
pubmed-meshheading:20548789-Antigens, CD14,
pubmed-meshheading:20548789-Case-Control Studies,
pubmed-meshheading:20548789-Disease Progression,
pubmed-meshheading:20548789-Flow Cytometry,
pubmed-meshheading:20548789-Humans,
pubmed-meshheading:20548789-Inflammation,
pubmed-meshheading:20548789-Liver Cirrhosis,
pubmed-meshheading:20548789-Monocytes,
pubmed-meshheading:20548789-Receptors, IgG
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis.
|
|
pubmed:affiliation |
Department of Medicine III, University Hospital Aachen, Aachen, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
