| pubmed-article:20548031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0160420 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0682690 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:20548031 | lifeskim:mentions | umls-concept:C1012103 | lld:lifeskim |
| pubmed-article:20548031 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20548031 | pubmed:dateCreated | 2010-7-5 | lld:pubmed |
| pubmed-article:20548031 | pubmed:abstractText | Biological role(s) of Fc gammaRI on mouse primary sensory neurons are not fully understood. Sensory neuron stimulation increases insulin-like growth factor-I (IGF-I) production, thereby reducing ischemia/reperfusion (I/R)-induced tissue injury in mice. In this study, we examined whether the Fc fragment of IgG (IgGFc) increases IGF-I production through sensory neuron stimulation, thereby reducing I/R-induced renal injury in mice. IgGFc increased the calcitonin-gene-related peptide (CGRP) release and cellular cAMP levels in dorsal root ganglion neurons isolated from wild-type (WT) mice, whereas, native IgG did not. Pretreatment with anti-Fc gammaRI Ab, a protein kinase A inhibitor KT5710, and a phospholipase A(2) inhibitor 4-bromophenylacyl bromide inhibited these effects induced by IgGFc. Administration of IgGFc enhanced increases of renal tissue levels of CGRP and IGF-I and reduced I/R-induced renal injury in WT mice. Increases of renal tissue level of caspase-3, renal accumulation of neutrophils, and renal tubular apoptosis were inhibited by administration of IgGFc in WT mice subjected to renal I/R. Pretreatment with anti-IGF-I Ab completely reversed these effects induced by IgGFc in WT mice. Administration of native IgG did not show any effects in WT mice subjected to renal I/R. None of the effects observed in WT mice was seen after IgGFc administration in CGRP-knockout mice and denervated WT mice. These observations suggest that activation of Fc gammaRI by IgGFc may stimulate sensory neurons, thereby promoting IGF-I production, contributing to reduction of the reperfusion-induced renal injury via attenuation of inflammatory responses in mice. | lld:pubmed |
| pubmed-article:20548031 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20548031 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20548031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20548031 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20548031 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:20548031 | pubmed:author | pubmed-author:OkajimaKenjiK | lld:pubmed |
| pubmed-article:20548031 | pubmed:author | pubmed-author:HaradaNaoakiN | lld:pubmed |
| pubmed-article:20548031 | pubmed:author | pubmed-author:NakagataNaomi... | lld:pubmed |
| pubmed-article:20548031 | pubmed:author | pubmed-author:KuriharaHirok... | lld:pubmed |
| pubmed-article:20548031 | pubmed:author | pubmed-author:ZhaoJuanJ | lld:pubmed |
| pubmed-article:20548031 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20548031 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20548031 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:20548031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20548031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20548031 | pubmed:pagination | 1303-10 | lld:pubmed |
| pubmed-article:20548031 | pubmed:dateRevised | 2011-11-9 | lld:pubmed |
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| pubmed-article:20548031 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20548031 | pubmed:articleTitle | Stimulation of Fc gammaRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice. | lld:pubmed |
| pubmed-article:20548031 | pubmed:affiliation | Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. | lld:pubmed |
| pubmed-article:20548031 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20548031 | pubmed:publicationType | Retracted Publication | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20548031 | lld:pubmed |
