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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-5
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pubmed:abstractText |
Biological role(s) of Fc gammaRI on mouse primary sensory neurons are not fully understood. Sensory neuron stimulation increases insulin-like growth factor-I (IGF-I) production, thereby reducing ischemia/reperfusion (I/R)-induced tissue injury in mice. In this study, we examined whether the Fc fragment of IgG (IgGFc) increases IGF-I production through sensory neuron stimulation, thereby reducing I/R-induced renal injury in mice. IgGFc increased the calcitonin-gene-related peptide (CGRP) release and cellular cAMP levels in dorsal root ganglion neurons isolated from wild-type (WT) mice, whereas, native IgG did not. Pretreatment with anti-Fc gammaRI Ab, a protein kinase A inhibitor KT5710, and a phospholipase A(2) inhibitor 4-bromophenylacyl bromide inhibited these effects induced by IgGFc. Administration of IgGFc enhanced increases of renal tissue levels of CGRP and IGF-I and reduced I/R-induced renal injury in WT mice. Increases of renal tissue level of caspase-3, renal accumulation of neutrophils, and renal tubular apoptosis were inhibited by administration of IgGFc in WT mice subjected to renal I/R. Pretreatment with anti-IGF-I Ab completely reversed these effects induced by IgGFc in WT mice. Administration of native IgG did not show any effects in WT mice subjected to renal I/R. None of the effects observed in WT mice was seen after IgGFc administration in CGRP-knockout mice and denervated WT mice. These observations suggest that activation of Fc gammaRI by IgGFc may stimulate sensory neurons, thereby promoting IGF-I production, contributing to reduction of the reperfusion-induced renal injury via attenuation of inflammatory responses in mice.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-bromophenacyl bromide,
http://linkedlifedata.com/resource/pubmed/chemical/Acetophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Fcgr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/KT 5720,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1303-10
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pubmed:dateRevised |
2011-11-9
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pubmed:meshHeading |
pubmed-meshheading:20548031-Acetophenones,
pubmed-meshheading:20548031-Animals,
pubmed-meshheading:20548031-Antibodies,
pubmed-meshheading:20548031-Apoptosis,
pubmed-meshheading:20548031-Calcitonin Gene-Related Peptide,
pubmed-meshheading:20548031-Carbazoles,
pubmed-meshheading:20548031-Caspase 3,
pubmed-meshheading:20548031-Cells, Cultured,
pubmed-meshheading:20548031-Cyclic AMP,
pubmed-meshheading:20548031-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20548031-Female,
pubmed-meshheading:20548031-Immunoglobulin Fc Fragments,
pubmed-meshheading:20548031-Immunoglobulin G,
pubmed-meshheading:20548031-Insulin-Like Growth Factor I,
pubmed-meshheading:20548031-Kidney,
pubmed-meshheading:20548031-Male,
pubmed-meshheading:20548031-Mice,
pubmed-meshheading:20548031-Mice, Inbred BALB C,
pubmed-meshheading:20548031-Mice, Inbred C57BL,
pubmed-meshheading:20548031-Mice, Inbred Strains,
pubmed-meshheading:20548031-Mice, Knockout,
pubmed-meshheading:20548031-Phospholipases A2,
pubmed-meshheading:20548031-Pyrroles,
pubmed-meshheading:20548031-Receptors, IgG,
pubmed-meshheading:20548031-Reperfusion Injury,
pubmed-meshheading:20548031-Sensory Receptor Cells
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pubmed:year |
2010
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pubmed:articleTitle |
Stimulation of Fc gammaRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
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pubmed:affiliation |
Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Retracted Publication
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