Linked Life Data

20547790

Source:http://linkedlifedata.com/resource/pubmed/id/20547790

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pubmed-article:20547790pubmed:abstractTextParallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 microg/liter versus 1,125 microg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly.lld:pubmed
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pubmed-article:20547790pubmed:dateRevised2011-7-25lld:pubmed
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pubmed-article:20547790pubmed:articleTitleTherapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method.lld:pubmed
pubmed-article:20547790pubmed:affiliationUniversity Medical Center Freiburg, Department of Hematology & Oncology, Freiburg, Germany. werner.neubauer@uniklinik-freiburg.delld:pubmed
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