|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-8-18
|
|
pubmed:abstractText |
Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 microg/liter versus 1,125 microg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-12936975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-15311563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-15656699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-16033292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-16436724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-16723557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-16961577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-17143808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-17251530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-17999982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-18462102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-18955533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-19075045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-19258264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-19738015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20547790-19752284
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1098-6596
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4029-32
|
|
pubmed:dateRevised |
2011-7-25
|
|
pubmed:meshHeading |
pubmed-meshheading:20547790-Adult,
pubmed-meshheading:20547790-Aged,
pubmed-meshheading:20547790-Antifungal Agents,
pubmed-meshheading:20547790-Chromatography, High Pressure Liquid,
pubmed-meshheading:20547790-Female,
pubmed-meshheading:20547790-Hematologic Neoplasms,
pubmed-meshheading:20547790-Humans,
pubmed-meshheading:20547790-Male,
pubmed-meshheading:20547790-Middle Aged,
pubmed-meshheading:20547790-Mycoses,
pubmed-meshheading:20547790-Prospective Studies,
pubmed-meshheading:20547790-Triazoles
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method.
|
|
pubmed:affiliation |
University Medical Center Freiburg, Department of Hematology & Oncology, Freiburg, Germany. werner.neubauer@uniklinik-freiburg.de
|
|
pubmed:publicationType |
Journal Article
|
