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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 16
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pubmed:dateCreated |
2010-8-16
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pubmed:abstractText |
The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming alpha1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming alpha1G subunit for T-type calcium channel were used. In vitro intracellular recording from IO neurons reveals that the amplitude and frequency of sinusoidal subthreshold oscillations (SSTOs) were reduced in the CaV2.1-/- mice. In the CaV3.1-/- mice, IO neurons also showed altered patterns of SSTOs and the probability of SSTO generation was significantly lower (15%, 5 of 34 neurons) than that of wild-type (78%, 31 of 40 neurons) or CaV2.1-/- mice (73%, 22 of 30 neurons). In addition, the low-threshold calcium spike and the sustained endogenous oscillation following rebound potentials were absent in IO neurons from CaV3.1-/- mice. Moreover, the phase-reset dynamics of oscillatory properties of single neurons and neuronal clusters in IO were remarkably altered in both CaV2.1-/- and CaV3.1-/- mice. These results suggest that both alpha1A P/Q- and alpha1G T-type calcium channels are required for the dynamic control of neuronal oscillations in the IO. These findings were supported by results from a mathematical IO neuronal model that incorporated T and P/Q channel kinetics.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1469-7793
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
588
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3031-43
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pubmed:dateRevised |
2011-8-25
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pubmed:meshHeading |
pubmed-meshheading:20547676-Animals,
pubmed-meshheading:20547676-Calcium Channels, P-Type,
pubmed-meshheading:20547676-Calcium Channels, Q-Type,
pubmed-meshheading:20547676-Calcium Channels, T-Type,
pubmed-meshheading:20547676-Calcium Signaling,
pubmed-meshheading:20547676-Computer Simulation,
pubmed-meshheading:20547676-Kinetics,
pubmed-meshheading:20547676-Membrane Potentials,
pubmed-meshheading:20547676-Mice,
pubmed-meshheading:20547676-Mice, Knockout,
pubmed-meshheading:20547676-Models, Neurological,
pubmed-meshheading:20547676-Neurons,
pubmed-meshheading:20547676-Olivary Nucleus
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pubmed:year |
2010
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pubmed:articleTitle |
Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.
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pubmed:affiliation |
New York University School of Medicine, Department of Physiology & Neuroscience, 550 First Ave, MSB 442, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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