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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
2010-7-19
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pubmed:abstractText |
The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-10742155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-11598038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-11895984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-12721940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-12761099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-13091327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-13475611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-1370521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-14461914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-15102757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-15232173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-15304468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-16163629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-16253886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-16359315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-16826480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-1696296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-17806049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-18193657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19132104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19480575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19515838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19778763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19797947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-19868354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-2430047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-2458320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-2660266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-3049817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-325168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-8958044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-9418133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546830-9987154
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-2518
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier Ltd.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5017-22
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20546830-Animals,
pubmed-meshheading:20546830-Antibodies, Bacterial,
pubmed-meshheading:20546830-Antigens, Bacterial,
pubmed-meshheading:20546830-Bacterial Outer Membrane Proteins,
pubmed-meshheading:20546830-Carrier Proteins,
pubmed-meshheading:20546830-Cross Protection,
pubmed-meshheading:20546830-Epitopes,
pubmed-meshheading:20546830-Female,
pubmed-meshheading:20546830-Mice,
pubmed-meshheading:20546830-Mice, Inbred BALB C,
pubmed-meshheading:20546830-Mice, Inbred ICR,
pubmed-meshheading:20546830-Pneumococcal Vaccines,
pubmed-meshheading:20546830-Rabbits,
pubmed-meshheading:20546830-Serum Bactericidal Test,
pubmed-meshheading:20546830-Streptococcal Infections,
pubmed-meshheading:20546830-Streptococcus pyogenes
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pubmed:year |
2010
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pubmed:articleTitle |
Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes.
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pubmed:affiliation |
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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