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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020433,
umls-concept:C0023884,
umls-concept:C0034696,
umls-concept:C0162326,
umls-concept:C0442335,
umls-concept:C0537026,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1521840,
umls-concept:C1882115,
umls-concept:C2700400
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pubmed:issue |
3
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
Crigler-Najjar type 1 (CN-I) is an inherited liver disease caused by an absence of bilirubin-uridine 5'-diphosphate-glucuronosyltransferase (UGT1A1) activity. It results in life-threatening levels of unconjugated bilirubin, and therapeutic options are limited. We used adult Gunn rats (an animal model of the disease) to evaluate the efficiency of lentiviral-based gene therapy to express UGT1A1 in liver.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:AnegonIgnacioI,
pubmed-author:BoniSébastienS,
pubmed-author:DarielAnneA,
pubmed-author:FerryNicolasN,
pubmed-author:FlageulMaudeM,
pubmed-author:LabrunePhilippeP,
pubmed-author:LaplancheSophieS,
pubmed-author:MyaraAnneA,
pubmed-author:NguyenTuan HuyTH,
pubmed-author:PichardVirginieV,
pubmed-author:PodevinGuillaumeG,
pubmed-author:RemySéverineS,
pubmed-author:SchmittFrançoiseF,
pubmed-author:UsalClaireC
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pubmed:copyrightInfo |
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
999-1007, 1007.e1-2
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pubmed:meshHeading |
pubmed-meshheading:20546738-Animals,
pubmed-meshheading:20546738-Antibodies,
pubmed-meshheading:20546738-Antigen-Presenting Cells,
pubmed-meshheading:20546738-Bilirubin,
pubmed-meshheading:20546738-Biological Markers,
pubmed-meshheading:20546738-Crigler-Najjar Syndrome,
pubmed-meshheading:20546738-Disease Models, Animal,
pubmed-meshheading:20546738-Gene Therapy,
pubmed-meshheading:20546738-Genetic Vectors,
pubmed-meshheading:20546738-Glucuronosyltransferase,
pubmed-meshheading:20546738-HeLa Cells,
pubmed-meshheading:20546738-Humans,
pubmed-meshheading:20546738-Lentivirus,
pubmed-meshheading:20546738-Liver,
pubmed-meshheading:20546738-Male,
pubmed-meshheading:20546738-MicroRNAs,
pubmed-meshheading:20546738-Prealbumin,
pubmed-meshheading:20546738-Promoter Regions, Genetic,
pubmed-meshheading:20546738-RNA, Messenger,
pubmed-meshheading:20546738-RNA Stability,
pubmed-meshheading:20546738-Rats,
pubmed-meshheading:20546738-Rats, Gunn,
pubmed-meshheading:20546738-Time Factors,
pubmed-meshheading:20546738-Transduction, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
Lentiviral vectors that express UGT1A1 in liver and contain miR-142 target sequences normalize hyperbilirubinemia in Gunn rats.
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pubmed:affiliation |
INSERM Unité 948, CHU Hôtel Dieu, Nantes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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