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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-6-15
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pubmed:abstractText |
Despite pharmaceutical treatment with NTBC (2-2-nitro-4-fluoromethylbenzoyl-1,3-cyclohexanedione), a high incidence of liver malignancies occur in humans and mice suffering from hereditary tyrosinemia type 1 (HT1) caused by mutation of the fumarylacetoacetate hydrolase (fah) gene.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1440-1746
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1002-8
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pubmed:meshHeading |
pubmed-meshheading:20546455-Animals,
pubmed-meshheading:20546455-Bilirubin,
pubmed-meshheading:20546455-Biological Markers,
pubmed-meshheading:20546455-Cell Proliferation,
pubmed-meshheading:20546455-Cyclohexanones,
pubmed-meshheading:20546455-Dependovirus,
pubmed-meshheading:20546455-Disease Models, Animal,
pubmed-meshheading:20546455-Gene Therapy,
pubmed-meshheading:20546455-Genetic Vectors,
pubmed-meshheading:20546455-Hepatocytes,
pubmed-meshheading:20546455-Hydrolases,
pubmed-meshheading:20546455-Injections, Intravenous,
pubmed-meshheading:20546455-L-Lactate Dehydrogenase,
pubmed-meshheading:20546455-Liver,
pubmed-meshheading:20546455-Liver Function Tests,
pubmed-meshheading:20546455-Mice,
pubmed-meshheading:20546455-Mice, Inbred BALB C,
pubmed-meshheading:20546455-Mice, Knockout,
pubmed-meshheading:20546455-Nitrobenzoates,
pubmed-meshheading:20546455-Plasmids,
pubmed-meshheading:20546455-Serum Albumin,
pubmed-meshheading:20546455-Tail,
pubmed-meshheading:20546455-Time Factors,
pubmed-meshheading:20546455-Transfection,
pubmed-meshheading:20546455-Tyrosinemias,
pubmed-meshheading:20546455-Urea
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pubmed:year |
2010
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pubmed:articleTitle |
High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice.
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pubmed:affiliation |
Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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